Increased IL-18 had also been observed in SLE patients from all age groups and whose disease duration was more than or less than five years (SMD = 2.20, 95% CI [1.40–3.00]; SMD = 1.28, 95% CI [0.89–1.67]; SMD = 2.35, 95% CI [1.13–3.57]; SMD = 1.72, 95% CI [1.11–2.34]; SMD = 1.24, 95% CI [0.73–1.75]). This evidence concerns the gene IL18 and systemic lupus erythematosus.