What’s more, if SLEDAI scores for SLE patients were over five which underlay more active disease severity, the level of IL-18 escalated higher than normal people (SMD = 1.46, 95% CI [0.47–2.44]; SMD = 1.42, 95% CI [0.77–2.08]; SMD = 1.76, 95% CI [1.29–2.23]). This evidence concerns the gene IL18 and systemic lupus erythematosus.