In addition, proliferating, cytotoxic T-cells (CD3 + CD8 + KI67 +), PD-L1 + T-cells (CD3 + PD-L1 +) and macrophages (CD68 +) expressing PD-L1 were more prevalent in the tumor-epithelial compartment than in the tumor-stroma compartment. This evidence concerns the gene CD8A and neoplasm.