Our data did not reveal a difference in plasma CXCL16 levels between individuals with arthralgia at risk of RA and HC; however, higher CRP levels and the positive correlation between CXCL16 with the CRP levels and ESR shown here in RA-risk individuals with arthralgia may reflect an inflammatory milieu in the preclinical phase. The gene discussed is CRP; the disease is rheumatoid arthritis.