Although the effect of GTE-EGCG is not specific, and different catechins or combinations of catechins may have different effects on Down syndrome phenotypes 7, accumulating evidence suggests that the ability of GTE-EGCG to inhibit the excess kinase activity 10 of the dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) may play a prominent role 11. Here, DYRK1A is linked to Down syndrome.