In the Notch1-induced T-cell acute lymphoblastic leukemia (T-ALL) mouse model, Notch1 increases Jmjd3 expression likely via NFkB, which in turn enhances the expression of Notch1 target genes in cooperation with Notch1, while Utx suppresses the T-ALL formation18. Here, NOTCH1 is linked to acute lymphoblastic leukemia.