With non-severe (non-ICU) COVID-19, there was increased expression of the viral entry gene (CTSL (p < 0.05)) and increased antiviral response genes (MX1 (p < 0.0001), SAMHD1 (p < 0.0001), TRIM25 (p < 0.01), IFITM3 (ns)). Here, SAMHD1 is linked to COVID-19.