While P38 MAPK is more sensitive to SB203580, JNK is more responsive to SP600125.42,43 In our study, we found that SB203580 exhibited stronger inhibition than SP600125 on the increased production of IL10 in MDSCs cultured with conditioned medium from PIWIL1-overexpressing HCC cells. This evidence concerns the gene MAPK8 and hepatocellular carcinoma.