A significant increase of CD11b + Ly6G + Ly6C- population was observed in BMDMs cultured with conditioned medium from PIWIL1-overexpressing HCC cells (Supplementary Fig. S4d), while the population of CD11b + Ly6G-Ly6Chi cells was reduced (Supplementary Fig. S4e). The gene discussed is ITGAM; the disease is hepatocellular carcinoma.