We then sorted intrahepatic PMN-MDSCs surrounding the wild type and PIWIL1-overexpressing HCC tumors, and the observed a more potent immunosuppressive activity of PMN-MDSCs from PIWIL1-overexpressing tumors to T-cell proliferation and activation than those from wild type tumors (Fig. 4h, i). The gene discussed is PIWIL1; the disease is hepatocellular carcinoma.