This effect of the anti-Ly6G antibody was also observed in some studies with other types of cancers.76,77 This property of the anti-Ly6G antibody may somehow compromise the data interpretation, because from the results we may conclude that PMN-MDSCs are an essential requirement for tumor promotion by PIWIL1, but whether it is a sufficient requirement is still unknown. This evidence concerns the gene PIWIL1 and cancer.