Suppression of FAO in the tumor microenvironment resulted in inhibition of MDSCs and activation of CD8 + cytotoxic T cells that delayed tumor growth.53 These findings cannot rule out the possibility of the antitumor effect of FAO inhibition within MDSCs, as several studies have suggested that the intracellular FAO in MDSCs could directly modulate its immunosuppressive activity in cancer therapies.54 Our findings in the current study suggest that modulation on the FAO of tumor cells may also play a role in regulating the immunosuppressive microenvironment. This evidence concerns the gene CD8A and cancer.