Some miRNAs such as miR-29 family (29a, 29b, and 29c) could target directly and indirectly DNA methylation-related enzymes such as TETs and DNMTs, and histone-modifying enzymes; for example, histone deacetylase 4 (HDAC4) and histone methyltransferase SET domain bifurcated 1 (SETDB1) are impaired in various cancer e.g., lung cancer, breast cancer, hepatocellular cancer, etc. [95–102]. Here, HDAC4 is linked to hepatocellular carcinoma.