Accordingly, in Cholangiocarcinoma (CCA) was declared that the overexpression and translocation of Dicer to the nucleus and formation complex with heterochromatin protein 1α (HP1α) leads to hypermethylation of SFRP1 promoter and suppression of its transcription through recruiting Dnmts [143]. This evidence concerns the gene SFRP1 and cholangiocarcinoma.