TPO and autoimmune thrombocytopenic purpura: Previous studies have found that TPO-RA treatment might play a role in improving regulatory T cell function to restore immune tolerance and could shift the balance of Fcγ receptors toward the inhibitory receptor IIb on monocytes in ITP patients [31, 32], indicating that TPO-RA might function in the processes of immune regulation in addition to increasing MK proliferation.