As expected, recombinant Pellino1 protein increased BAL neutrophil, BAL protein concentrations, lung bacterial CFU, BAL fluid Hgb concentration, lung injury, BAL fluid OD540 and lung tissue homogenates at OD620, and inhibited circulating platelet counts in lung injury of sepsis mice (Fig. 2I and P). Here, PELI1 is linked to Sepsis.