The leading SNP of CAD in HTN (17q25.3/CBX8-CBX4 rs1550676) showed the strongest association (P = 6.37 × 10−9) and a high odds ratio (OR) of 2.607 (95% CI 1.886–3.602), and a total of 4 significant SNPs were clustered in the locus. Here, CBX4 is linked to hypertensive disorder.