New insights have been offered into RPTOR and CVD/atherosclerosis; such as evidence that miR-100 exerts anti-angiogenic properties through suppression of mTOR, [25] and that inhibition of cardiac GSK-3β during continued myocardial ischemia attenuates ischemia-induced mTORC1 inhibition and increases ischemic injury [35]. This evidence concerns the gene GSK3B and myocardial ischemia.