RUNX2 and coronary artery disorder: In DL, all 3 GWASs identified genome-wide significant loci: in DL-CAD (Fig. 2g), 1 significant locus (9q22.2) and 24 suggestive loci; in DL-IS (Fig. 2h), 1 significant locus (3p22.1) and 40 suggestive loci; and in DL-CCD (Fig. 2i), 1 significant locus (2p22.2) and 19 suggestive loci.