Similarly, the G4 ligand nitidine, or TINA-modified oligonucleotides (insertion of (R)-1-O-(4-(1-pyrenylethynyl)phenylmethyl]glycerol to increase stability) that mimic G4 structures of KRAS down-regulate KRAS protein expression and inhibit pancreatic cancer cell growth [155, 160]. The gene discussed is KRAS; the disease is familial pancreatic carcinoma.