Melanomas are generally characterized by a high mutational burden [111, 112] and have frequently been used as an example for a highly mutated cancer that blocks DNA-damage induced apoptosis by mutations in different proteins, including TP53 [113, 114], POU3F2/BRN2 [115], RHOJ [116] and RSK [117]. This evidence concerns the gene POU3F2 and melanoma.