Compared with normal tissues, SLC7A7 was overexpressed in brain and CNS, breast, colorectal, esophageal, gastric, head and neck, leukemia, lymphoma, melanoma and pancreatic cancers, while some data sets showed that SLC7A7 was underexpressed in colorectal, kidney, leukemia, sarcoma and lung cancers based on Oncomine (Fig. 1a). Here, SLC7A7 is linked to familial pancreatic carcinoma.