We conducted preliminary experiments in several CRC cell lines and detected that ORP-1, MYB, and CDX-2 were downregulated in NCIH508wtRAS/RAF (a cell line sensitive to cetuximab), while SATB-2 expression decreased in CACO2 wtRAS/RAF (a cell line partially sensitive to cetuximab) and HT29 wtRAS/mtRAF (a cell line resistant to cetuximab) at the half-maximal inhibition concentration of cetuximab. This evidence concerns the gene SATB2 and colorectal carcinoma.