VEGFA and retinal detachment: Phase II is mainly due to the relative hypoxia induced by cessation of relative hyperoxia, stagnation of early angiogenesis, the maturation of neurons in the peripheral vascular free area of the retina, and increased energy demand, leading to overexpression of vascular promoting factors such as VEGF and consequently resulting in pathological neovascularization and eventual retinal detachment or blindness in severe cases [1].