Specifically, as mentioned before, the DR-BC cells were pre-administered with compound C (10 μmol/L) and SBI-0206965 (6 μmol/L) for 24 h to inactivate AMPK-ULK1 pathway, and subsequently stimulated with high-dose doxorubicin (20 μg/ml) for 48 h. The gene discussed is ULK1; the disease is breast cancer.