Of note, the DR-BC cells were treated with low-dose Dox (1 μg/ml) for 48 h, and we expectedly found that low-dose Dox did not influence both LC3B-II/I ratio and p62 levels in the DR-BC cells (Fig. S3A-C), suggesting that low-dose Dox was unable to trigger autophagy in the DR-BC cells. This evidence concerns the gene MAP1LC3B and breast cancer.