Non-infectious IOI can develop after intravitreal injections of ocriplasmin, bevacizumab, ranibizumab, triamcinolone acetonide, and aflibercept.1,3,4,5,6,7,8,9,10,11,12,13,14 Its incidence after anti-VEGF injection varies between 0.09% and 0.37% in the literature.3,4,5 In the present study, it occurred after intravitreal anti-VEGF injection for wet AMD at a rate of 0.1% of all injections and 0.66% of all patients. Here, VEGFA is linked to wet macular degeneration.