VEGFA and Hyalitis: It occurs as a rare complication of intravitreal pharmacological agents.1 As more intravitreal injections are performed, the number of such side effects is also increasing.1,2 Non-infectious IOI has been reported in response to all anti-vascular endothelial growth factor (anti-VEGF) drugs 1,3,4,5,6,7,8,9,10,11, triamcinolone 12,13, and ocriplasmin.14 It typically occurs within a few days after injection, manifesting with visual impairment and vitritis without conjunctival injection and substantial pain.3 The reported incidence ranges from 0.09% to 0.55%.1,8,9,10,11