Significant changes in the expression of 2,294 genes (1,221 up-regulated and 1,037 down-regulated) were identified in HD versus non-dementia controls (Figure 2B); whilst 2,173 DEGs (1,028 up-regulated and 1,145 down-regulated) were determined in BDNF-low versus high group (Figure 2C). The gene discussed is BDNF; the disease is dementia.