For example, with frontotemporal lobar degeneration pathology (Coyle-Gilchrist et al., 2016) including Frontotemporal lobe Dementia (FTD), Progressive Supranuclear Palsy (PSP) and Corticobasal Degeneration (CBD), there is 30%–50% loss of synapses, as determined by postmortem synaptophysin assays (Bigio et al., 2001; Lipton et al., 2001). The gene discussed is SYP; the disease is frontotemporal dementia.