MAPT and supranuclear palsy, progressive, 1: Pathologically, both PSP-RS and CBD are associated with accumulation of both cortical and subcortical 4-repeat tau (Dickson et al., 2011; Kovacs et al., 2020; Rösler et al., 2019; Schofield et al., 2012), and clinically present with a movement disorder (Armstrong et al., 2013; Höglinger et al., 2017; Litvan et al., 1996) and cognitive decline (Burrell et al., 2014).