SNCA and frontotemporal dementia: Notwithstanding the need for further confirmation in larger independent samples, this preliminary finding is consistent with our previous work across the spectrum of frontotemporal dementia (Bevan-Jones et al., 2020), and together mirror the tendency for activated microglia to coalesce around NFT-bearing neurons (Sheffield et al., 2000), which in turn interact synergistically with Aβ (Gomperts et al., 2008) and alpha-synuclein (Colom-Cadena et al., 2013; Howlett et al., 2015).