In the basal levels, iron-deficiency responses (i.e., IRP2 accumulation, increased TfR1, and reduced FT light chain), were apparent in iBAT, but not in eWAT and iWAT (Fig. 2A, Left), which is consistent with the intense IRP/IRE-binding pattern (Fig. 1A). The gene discussed is IREB2; the disease is nutritional disorder.