Also, the significant down-regulation of SIRT1 (2.6×10−5± 6.7×10−6) and CPNE3 (0.0035± 0.0001) were observed in ATLL samples than those in the normal samples (SIRT1: 0.29± 0.13) and (CPNE3:0.28± 0.09), all with p< 0.0001 (Fig 4C and 4D). The gene discussed is CPNE3; the disease is adult T-cell leukemia/lymphoma.