The results showed the remarkable up-regulation of FZD6 (0.17± 0.04) and THBS4 (1.48± 0.10) in ATLL samples than those in the normal samples (0.0018± 0.0005) and (0.10 ± 0.04) with p = 0.0007 and p = 0.0001, respectively (Fig 4A and 4B). Here, THBS4 is linked to adult T-cell leukemia/lymphoma.