SOD1 and amyotrophic lateral sclerosis: The MD simulations performed in this study can contribute to a better understanding of the molecular basis of ALS-SOD1 since this method provides detailed information on protein conformation and fluctuations over time [20], which can complement the results of already performed wet-lab experiments and overcome some limitations such as the static images provided by X-ray crystallography and the limited size of peptic fragments that can be analyzed by hydrogen/deuterium exchange [95].