In addition, some genes showed extensive cross-tissue effects on AD, such as AD was associated with the expression of APOE, CEACAM19, CLPTM1, DMWD, KAT8, PRSS36, PVRL2, SIX5, TRAPPC6A, PPP1R13L and PPP1R37 in at least three tissues. The gene discussed is PRSS36; the disease is Alzheimer disease.