SIX5 and Alzheimer disease: Module 1 (M1) included 13/24 prioritized AD-related genes (APOE, BCAM, CEACAM19, DMPK, DMWD, ERCC2, EXOC3L2, PPP1R13L, PPP1R37, PTPN9, PVR, QPCTL and SIX5), module 2 (M2) contained 3/24 prioritized AD-related genes (CD3EAP, TOMM40 and SNRPD2) and module 3 (M3) contained 1/24 prioritized AD-related genes (KAT8) (Fig 5C).