Among the 24 AD- and hippocampus-related genes identified in this study, previous studies only provide clues for the associations of hippocampal expression of PRSS36, KAT8, HLA-DRB5 [4], TOMM40 [20], CEACAM19 and PVRL2 [21] with AD. The gene discussed is PRSS36; the disease is Alzheimer disease.