For example, AD was affected by the gene expression of CD3EAP in the hippocampus and amygdala; TOMM40, PVR and RELB in the hippocampus and nucleus accumbens; DMPK and SNRPD2 in the hippocampus and putamen; and QPCTL and BCAM in the hippocampus and caudate. The gene discussed is TOMM40; the disease is Alzheimer disease.