Administration of XMU-MP-1 entirely recovered the severe colitis phenotypes in PPM1A KO mice, including the daily DAI (Fig 6A) and body weight loss (Fig 6B), largely prevented the DSS-induced disruption of crypts and villus architectures in PPM1A KO mice (Fig 6G and S4B Fig), and nicely maintained the proliferating intestinal epithelium (Fig 6G). Here, PPM1A is linked to colitis.