Based on the DEGs enrichment analyses, construction of ceRNA and verification of candidate biomarkers, we identified that signal transduction in the immune system played an important role in the occurrence and development of PAH, and CCR7, hsa‐let‐7e‐5p and SNHG12 were considered to serve as potential biomarkers in PAH. This evidence concerns the gene SNHG12 and pulmonary arterial hypertension.