DICER1 and hypothyroidism: To more thoroughly explore the consequence of germline DICER1 missense variation, we investigated the probability of thyroid disease (defined as an incidence of goiter, hypothyroidism, cysts, benign thyroid tumors, or thyrotoxicosis) in carriers of DICER1 missense variants predicted to be damaging by 3 bioinformatic tools (using the thresholds recommended by the developers of metaSVM, CADD, and REVEL), compared with sex-, race-, and age-matched noncarriers (Figure 2).