These issues will become only more magnified and urgent for DICER1 and other genes, with widespread population-scale sequencing, obligatory return of secondary findings,35 and germline results in tumor sequencing.36 The solution is to optimize the risk-benefit ratios in an age-, sex-, and race-specific way through the development of accurate penetrance estimates using additional biomarkers, better imaging, and surveillance modalities. Here, DICER1 is linked to neoplasm.