MAPT and Cognitive impairment: Interestingly, Zhao et al. (2016) have recently mapped a proteolysis site for caspase in the human Tau isoform 0N4R (amino acid sequence: HVPGGGSVQIVYKPVD), which generates a 35-kDa Tau fragment correlated with cognitive impairment in mice and humans presenting tauopathies [11].