LRRC8A and agammaglobulinemia: Lrrc8a (leucine-rich repeat-containing protein 8A, also known as SWELL1) encodes a transmembrane protein first described as the site of a balanced translocation in an immunodeficient child with agammaglobulinemia and absent B-cells (Sawada et al., 2003; Kubota et al., 2004).