The phenotype of endothelial-targeted Lrrc8a KO (eLrrc8a KO) mice are consistent with a reduction in eNOS and p-eNOS as these mice exhibit mild hypertension at baseline (females) and exacerbated hypertension in response to chronic angiotensin infusion, suggesting a modulatory effect on vascular reactivity. This evidence concerns the gene NOS3 and hypertensive disorder.