Specifically, type-A lamin and its splice variant Progerin, the cause of Hutchinson Gilford progeria syndrome (HGPS), a premature aging syndrome, are degraded by the HECT-type E3 ligase Smurf2 via ubiquitin-dependent autophagy (Borroni et al., 2018). Here, SMURF2 is linked to Hutchinson-Gilford progeria syndrome.