NCAM1 and Cognitive impairment: Interestingly, just as the postsynaptic NCAM180 exhibits the most blast‐mediated vulnerability, such isoform‐selective reduction has been reported in aged mice (17, 18), in the hippocampus of chronically stressed mice in which the reduction in NCAM expression was linked to cognitive impairment (18), and also appears to occur in the distal hippocampus after severe controlled cortical impact injury (32).