PCSK1 and stroke disorder: In the context of ischemic brain injury, Alexei Degterev and Junying Yuan firstly identified Nec-1 as a compound that blocks necrotic cell death in human and murine cells, and Nec-1 was shown to attenuate infarct volume in the transient middle cerebral artery occlusion (MCAO) model of stroke with a significant time window [33].