CYP1A1 and candidiasis: Therefore, the natural inhibitors of ERG6 gene product, such as C. carvi EO, introduced in the present study allows for the clinical treatment of candidiasis in a safer manner at a lower dosage [ 26]. On the other hand, it has been shown that C. carvi EO suppresses the expression of cytochrome P450 1A1 (CYP1A1) at the transcription level [ 38], which is responsible for the hepatotoxic effects of azole antifungal agents [ 39].