Moreover, the top ten pathways out of the total of 31 ROS-promoted pathways were involved in LIUS-downregulated IGs in BM cells including the role of pattern recognition receptors, triggering receptor expressed on myeloid cells 1 (TREM1) signaling, neuroinflammation, Toll-like receptor signaling, NF-κB signaling, production of nitric oxide (NO) and reactive oxygen species, high-mobility group protein 1 (HMGB1) signaling, colorectal cancer metastasis, macrophage migration inhibitory factor (MIF) regulation of innate immunity, and inducible NO synthase (INOS) signaling. This evidence concerns the gene HMGB1 and colorectal cancer.