As displayed in Figure 8, the results showed that in lymphoma cells, overexpression of B7-H4 upregulated 10.4% (as opposed to downregulating 1.3%) of 77 LIUS-upregulated IGs, suggesting that LIUS upregulates the innatome potentially via the reverse signaling of B7-H4. This evidence concerns the gene VTCN1 and lymphoma.