INS and Insulin resistance: Besides, several arachidonic acid metabolites, including PGE2, PGI2, and LXA4, PGE2 and PGI2 can alleviate insulin resistance and improve insulin sensitivity of pancreatic cells [28]; LXA4 can inhibit the production of IL-6, TNF-α, and ROS, thus alleviating inflammation, and has an antidiabetic effect [31, 32].