SERPINE1 and obstructive sleep apnea syndrome: At the same time, studies have found that there are oxidative stress reactions leading to tissue ischemia and hypoxia in patients with OSAHS, including reactive oxygen species (ROS), vascular endothelial growth factor (VEGF), advanced glycation end products (AGEs), and plasminogen activator inhibitor-1 (PAI-1), which leads to the occurrence and development of diabetic vascular disease [11, 12].