In each transplanted tumor group, the protein levels of VEGF, HIF-1, DLL4, and Notch-1 in the YQCTF-treated group were significantly lower than those in the control group (P < 0.05), and the inhibitory effect of YQCTF treated group was similar to that of the positive drug Sorafenib-treated group. Here, NOTCH1 is linked to neoplasm.