And then, we analyzed that HPRT1, STC2, PLCB3, GPR87, PYGL, and SLC5A12 are highly expressed in HNSCC tissues; besides, HPRT1, STC2, PLCB3, GPR87, PYGL, and SLC5A12 may be related to the poor prognosis of HNSCC. This evidence concerns the gene GPR87 and head and neck squamous cell carcinoma.