It is found that HPRT1, STC2, PLCB3, GPR87, PYGL, and SLC5A12 may be correlated with the poor prognosis of HNSCC (p = 0.004, <0.001, 0.027, 0.035, 0.030, and 0.009, respectively) (Figure 7(a)). The gene discussed is PLCB3; the disease is head and neck squamous cell carcinoma.