In ccRCC, it was also reported that a three-gene risk signature, including METTL3, METTL14, and HNRNPA2B1, or a risk signature with two m6A methylation regulators (METTL3 and METTL14) not only was an independent prognostic factor but was also closely associated with clinicopathological features [40–42]. This evidence concerns the gene METTL3 and nonpapillary renal cell carcinoma.