The short tail recruits an ITAM-linked FcRγ, which activates signaling through Syk and possibly the Caspase recruitment domain family member 9/B-Cell CLL/lymphoma 10/Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (CARD9/BCL10/MALT1) complex. The gene discussed is CARD9; the disease is B-cell chronic lymphocytic leukemia.