Further evidence suggested that there was a relationship between these changes in T cells and FAP progression, that compared with the adoptive transfer of splenocytes isolated from WT mice into chemically induced CRC immunodeficient mice and the adoptive transfer of splenocytes from ApcMin/+ mice into a CRC mice model resulted in the inability to prevent epithelial dysplasia (25). This evidence concerns the gene FAP and colorectal carcinoma.