In the opposite direction, TargetScan (www.targetscan.org) analysis of MIR211-5p and MIR204-5p also yields the following common oncogene or oncogene-like genes as high-confidence targets: Ras-Related Protein Rab-22A (RAB22A), Paired Like Homeobox 2B (PHOX2B) whose high expression is associated with neuroblastoma (105), and Adaptor Related Protein Complex 1 Subunit Sigma 2 (AP1S2) whose mRNA expression is enhanced in melanoma and is associated with significantly poorer survival of melanoma patients (although confers a better survival probability to ovarian and breast cancer patients). This evidence concerns the gene RAB22A and melanoma.