Among these shared targets are the mRNAs of the following tumor-suppressing genes: XIAP Associated Factor 1 (XAF I) (71, 100, 101), whose loss of function mutation causes gastric carcinoma, HRAS-Like-Suppressor4 (or HRASLS4) (71, 101, 102), also associated with mutations in gastric cancer, Homeodomain Interacting Protein Kinase 2 (HIPK2) (71, 103), mutations in which gene are associated with keratocanthoma (a rare skin cancer), breast cancer, and Thioredoxin Interacting Protein (TXNIP) (71, 104), associated with exocervical carcinoma. This evidence concerns the gene TXNIP and skin neoplasm.