HIPK2 and skin cancer: Among these shared targets are the mRNAs of the following tumor-suppressing genes: XIAP Associated Factor 1 (XAF I) (71, 100, 101), whose loss of function mutation causes gastric carcinoma, HRAS-Like-Suppressor4 (or HRASLS4) (71, 101, 102), also associated with mutations in gastric cancer, Homeodomain Interacting Protein Kinase 2 (HIPK2) (71, 103), mutations in which gene are associated with keratocanthoma (a rare skin cancer), breast cancer, and Thioredoxin Interacting Protein (TXNIP) (71, 104), associated with exocervical carcinoma.