The recently discovered MYC inhibitor 361 (MYCi361) binds to the HLH region of the MYC protein (AA366-378), disrupts MYC/MAX heterodimerization, enhances degradation of both MYC and MYCN, and suppresses MYC-dependent tumor cell growth in vitro and in vivo (128). This evidence concerns the gene MYCN and neoplasm.