MYC and leukemia: Although a cationic porphyrin TmPyP4, which binds non-selectively to G4s in vitro was able to inhibit the transcription of c-MYC (108), a recent study identified a small molecule DC-34 that more specifically binds to the c-MYC G4 in vitro. In a G4-dependent mechanism, DC-34 plays a more potent and selective role in downregulating MYC gene transcription compared to other G4 containing oncogenes in leukemia cells.