Among compounds that restore wild-type function of p53 there are agents such as CP-31398 (stabilize the DNA-binding core domain and induce conformational changes) (105), PETIC (sensitize the p53 mutant to proteasome-mediated degradation and restore p53 WT conformation) (106), RITA (reactivate p53 in mutant p53 cancers by inhibiting the p53-HDM2 interaction) (107), and COTI-2 (restore WT p53 activity by targeting and binding to misfolded p53 mutant) (108). This evidence concerns the gene MDM2 and cancer.