TP53 and myelodysplastic syndrome: Recently, the International Working Group for Prognosis in MDS (IWG-PM) assessed 3,324 MDS patients for TP53 mutations and allelic imbalances of the TP53 locus observing that one in three patients harboring TP53 mutations displayed mono-allelic targeting of the gene whereas two in three showed multiple hits reflecting bi-allelic targeting.