In fact, TP53 alterations may co-exist with some other frequent AML-related single-nucleotide mutations such as TET2, NPM1, FLT3, DNMT3A, IDH1, and IDH2; in addition, TP53-mutant AML are often characterized by recurrent co-occurring karyotypic structural aberrations, especially genomic abnormalities detected in certain chromosomes (chromosome 5, 7, and 17), and with events involving chromothripsis (36–38). This evidence concerns the gene IDH1 and acute myeloid leukemia.