TP53 and acute myeloid leukemia: Interestingly, although karyotypic instability has been associated with TP53 inactivation, only distinct forms of increased mutagenesis have been identified among TP53-mutated AML; TP53-mutations tend to co-exist with augmented numbers of major karyotipic abnormalities, marker chromosomes and chromothripsis (39), but not with a potentially rise in single-nucleotide mutations (40).