AKT1 and glioblastoma: Multiple studies found exosomes could increase radioresistance in GBM), lung cancer and HNSCC through exosomal miRNAs (e.g., miR-208a and miR-889), non-coding RNAs (e.g., circATP8B4 and AHIF), mRNA (e.g. CCND1, WWC1 and DNM2), and pathways crosstalk (e.g., AKT/mTOR and STAT1/NOTCH3) (116–120).