IL10 and neoplasm: For example, EVs released by ovarian cancer cells could transfer oncogenic miR-1246 to M2-type tumor-associated macrophages (TAMs) and induce the secretion of tumor-supportive factors, including IL-10 and metalloproteinases (MMPs), while miR-25-3p and miR-921-3p present in EVs secreted by liposarcoma cells could stimulate the secretion of the pro-inflammatory cytokine IL-6 from macrophages, thus triggering tumor progression (49–51).