LY2109761 treatment at 5 and 10 μM significantly inhibited the mRNA and protein expression of key keloid-related factors, including TGF-β (Figures 1(a)–1(d)), collagen I (10 μM only; Figures 1(a)–1(c)), collagen III (Figures 1(a)–1(c)), fibronectin (Figures 1(a)–1(c)), MMP-1 (Figures 1(a)–1(c)), and MMP-3 (Figures 1(a)–1(c)) compared with control treatment (P > 0.05). This evidence concerns the gene MMP3 and keloid.