A recent systematic review and meta-analysis study that included three randomized controlled trials (RCTs) and three prospective cohort studies (1663 total participants) revealed that there is low-quality evidence that demonstrates that withdrawal of ACE inhibitor/ARB medications prior to coronary angiography and cardiac surgery reduces the incidence of AKI and there was no evidence that drug discontinuation reduces the incidence of AKI during intercurrent illness in primary or secondary care [11]. The gene discussed is ACE; the disease is acute kidney injury.