Besides, miR-214-3p is down- expressed in the post-menopausal women’s epithelial-mesenchymal transition (EMT) process and the development of interstitial cystitis (IC), and mitofusin 2 (Mfn2) is the target gene of miR-214-3p, so down-regulation of miR-214-3p promotes the EMT process and bladder wall fibrosis, leading to IC in postmenopausal women (Lv et al., 2017). Here, MFN2 is linked to interstitial cystitis.