TNF and rheumatoid arthritis: Wielińska et al. (2020) reported larger differences between genotypes for genes coding for the receptor activator of nuclear factor κB (RANK rs8086340) and its ligand (RANKL rs7325635) in rheumatoid arthritis patients prior to 12 weeks of anti-TNF treatment when average CRP concentrations were high (23.6 mg/L), than after treatment when average concentrations were lower (9.84 mg/L, Figs. 8A and 8B).