CRP and diabetes mellitus: Qi, Rifai & Hu (2007) reported a significant interaction (Pinteraction = 0.03) between diabetes and rs8192284 in their effect on CRP concentrations (Fig. 6B histogram). However, diabetic had higher estimated CRP concentrations than non-diabetics, and the interaction could be due to the larger genetic effect size at the higher average CRP concentrations of the T2DM (Fig. 6B line graph).