TIMP1 and colorectal carcinoma: In addition, based on the potential inhibitory effect on chemotherapy-induced apoptosis, TIMP-1 serves as an effective biomarker to predict the response to chemotherapy (chemo) in CRC and has attracted tremendous attention, but no consistent conclusion has yet been reached (Frederiksen et al., 2011; Spindler et al., 2015; Unsal et al., 2008).